beta adrenergic receptor kinase-2 (G protein-coupled receptor kinase-3, ADRBK2, BARK2, GRK3)

Function

• specifically phosphorylates agonist-occupied form of the beta-adrenergic receptors & closely related receptors

ATP + [beta-adrenergic receptor]
              <-->
ADP + [beta-adrenergic receptor] phosphate

Structure

• belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily
• contains 1 AGC-kinase C-terminal domain
• contains 1 PH domain
• contains 1 protein kinase domain
• contains 1 RGS domain

More general terms

• G protein-coupled receptor kinase

Database

• UniProt: http://www.uniprot.org/uniprot/P35626.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:157
• OMIM: https://mirror.omim.org/entry/109636
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=157