myotubularin-related protein 5; SET-binding factor 1; Sbf1 (SBF1, MTMR5)

Function

• probable pseudophosphatase
• lacks several amino acids in the catalytic pocket which renders it catalytically inactive as a phosphatase
• the pocket is however sufficiently preserved to bind phosphorylated substrates, & maybe protect them from phosphatases
• inhibits myoblast differentiation in vitro & induces oncogenic transformation in fibroblasts
• interacts with the SET domain of MLL/HRX
• interacts with SUV39H1

Structure

• belongs to the protein-tyrosine phosphatase family non-receptor class myotubularin subfamily
• contains 1 dDENN domain
• contains 1 DENN domain
• contains 1 GRAM domain
• contains 1 myotubularin phosphatase domain
• contains 1 PH domain
• contains 1 uDENN domain

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• myotubularin family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6305
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6305
• OMIM: https://mirror.omim.org/entry/603560
• UniProt: http://www.uniprot.org/uniprot/O95248.html