phospholipase A1 member A (phosphatidylserine-specific phospholipase A1, PS-PLA1, PLA1A, NMD, PSPLA1)

Function

• hydrolyzes ester bond at the sn-1 position of glycerophospholipids & produces 2-acyl lysophospholipids
• hydrolyzes phosphatidylserine in the form of liposomes & 1-acyl-2 lysophosphatidylserine, but not triolein, phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid or phosphatidylinositol
• isoform 2 hydrolyzes 1-acyl-2 lysophosphatidylserine but not phosphatidylserine
• hydrolysis of 1-acyl-2 lysophosphatidylserine peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production

Structure

• belongs to the AB hydrolase superfamily, lipase family

Compartment

secreted

Alternative splicing

named isoforms=3

Expression

• widely expressed
• expressed in placenta, prostate & liver
• weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle & kidney

More general terms

• phospholipase A1 (PLA1, phosphatidylcholine 1-acylhydrolase)

Database

• OMIM: https://mirror.omim.org/entry/607460
• UniProt: http://www.uniprot.org/uniprot/Q53H76.html