cathepsin-E (CTSE)
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Function
- may have a role in immune function
- probably involved in processing of antigenic peptides during MHC class II-mediated antigen presentation
- may play a role in activation-induced lymphocyte depletion in the thymus
- similar to cathepsin D, but slightly broader specificity
Structure
- homodimer, disulfide-linked
- glycosylated
- proenzyme contains a high mannose-type oligosaccharide
- mature enzyme contains a complex-type oligosaccharide
- belongs to the peptidase A1 family
Compartment
- endosome
- proenzyme is localized to the endoplasmic reticulum & Golgi
- mature enzyme is localized to the endosome
Alternative splicing
named isoforms=3
Expression
- expressed in stomach, Clara cells of the lung & activated B-lymphocytes > lymph nodes, skin & spleen
- not expressed in resting B-lymphocytes
Pathology
- may play a role in neuronal degeneration & glial cell activation in the brain