nuclear receptor subfamily 1 group I member 2; orphan nuclear receptor PXR; pregnane X receptor; orphan nuclear receptor PAR1; steroid & xenobiotic receptor; SXR (NR1I2, PXR)

Function

• orphan receptor
• natural ligand is probably pregnane
• binds to a response element in the promoter of CYP3A4 & ABCB1/MDR1 genes
• forms a heterodimer with RXR

Structure

• belongs to the nuclear hormone receptor family, NR1 subfamily
• contains 1 nuclear receptor DNA-binding domain

Compartment

nucleus (putative)

Alternative splicing

named isoforms=7; 1A,1B,1C,2A,2B,2C

Expression

• expressed in liver, colon & small intestine
• expression activated by naturally occurring steroids such as pregnenolone & progesterone

More general terms

• steroid receptor
• nuclear hormone receptor NR1 subfamily
• zinc finger protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8856
• OMIM: https://mirror.omim.org/entry/603065
• UniProt: http://www.uniprot.org/uniprot/O75469.html