C-X-C chemokine receptor type 5; CXC-R5; CXCR-5; Burkitt lymphoma receptor 1; monocyte-derived receptor 15; MDR-15; CD185 (CXCR5, BLR1, MDR15)

Function

• cytokine receptor
• binds to B-lymphocyte chemoattractant (BLC)
• role in B-cell migration into B-cell follicles of spleen & Peyer patches but not into those of mesenteric or peripheral lymph nodes
• may have a regulatory function in B-cell differentiation

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Alternative splicing

named isoforms=2; long & short

Expression

• expression in mature B-cells

Pathology

• expressed in Burkitt lymphoma cells
• may have a regulatory function in Burkitt lymphoma

More general terms

• G-protein coupled receptor; serpentine receptor
• CXC chemokine receptor
• glycoprotein
• CD antigen

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:643
• OMIM: https://mirror.omim.org/entry/601613
• UniProt: http://www.uniprot.org/uniprot/P32302.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=643