G-protein coupled receptor 183; EBV-induced G-protein coupled receptor 2 (GPR183, EBI2)

Function

• orphan receptor
• probable mediator of normal lymphocyte functions
• signals constitutively through Gi-alpha, but not Gs-alpha or Gq-alpha

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• expressed abundantly in lymphoid tissues including spleen & lymph node, & in B- & T-lymphocytes
• also highly expressed in lung, heart, gastrointestinal tract
• weakly expressed in urogenital system & brain
• induced by EBV

Pathology

• probable mediator of EBV effects on B lymphocytes

Notes

• uncertain whether Met-1 or Met-5 is the initiator

More general terms

• G-protein coupled receptor; serpentine receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1880
• OMIM: https://mirror.omim.org/entry/605741
• UniProt: http://www.uniprot.org/uniprot/P32249.html