apelin receptor; APJ receptor; G-protein coupled receptor APJ; angiotensin receptor-like 1; HG11 (APLNR, AGTRL1, APJ)

Function

• receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity (Gi proteins)

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• widely expressed in the brain, in glial cells, astrocytes & neuronal subpopulations
• also expressed in spleen, thymus, ovary, small intestine & colon

Pathology

• alternative coreceptor with CD4 for HIV-1 infection
• may be involved in the development of AIDS dementia

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:187
• OMIM: https://mirror.omim.org/entry/600052
• UniProt: http://www.uniprot.org/uniprot/P35414.html