fMet-Leu-Phe receptor; fMLP receptor; N-formyl peptide receptor; FPR; N-formylpeptide chemoattractant receptor (FPR1)

Function

• high affinity receptor for N-formyl-methionyl peptides, which are neutrophils chemotactic factors
• binding of FMLP to the receptor causes activation of neutrophils
• this response is mediated via a G-protein that activates a phosphatidylinositol-Ca+2 second messenger system
• phosphorylation is necessary for desensitization

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane; multi-pass membrane protein

Expression

neutrophils

More general terms

• G-protein coupled receptor; serpentine receptor
• phosphoprotein
• glycoprotein

Additional terms

• N-formyl peptide receptor 2; FMLP-related receptor I; FMLP-R-I; formyl peptide receptor-like 1; lipoxin A4 receptor; LXA4 receptor; RFP; HM63 (FPR2 FPRH1 FPRL1 LXA4R)
• N-formyl peptide receptor 3; FMLP-related receptor II; FMLP-R-II; formyl peptide receptor-like 2 (FPR3, FPRH1, FPRL2)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2357
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2357
• OMIM: https://mirror.omim.org/entry/136537
• UniProt: http://www.uniprot.org/uniprot/P21462.html