N-formyl peptide receptor 2; FMLP-related receptor I; FMLP-R-I; formyl peptide receptor-like 1; lipoxin A4 receptor; LXA4 receptor; RFP; HM63 (FPR2 FPRH1 FPRL1 LXA4R)

Function

• low affinity receptor for N-formyl-methionyl peptides, (neutrophil chemotactic factors)
• binding of FMLP to the receptor causes activation of neutrophils
• response is mediated via a G-protein that activates a phosphatidylinositol-Ca+2 second messenger system
• activation of LXA4R could result in an anti-inflammatory outcome, counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4)

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• expressed abundantly in the lung & neutrophils
• also found in the spleen & testis

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2358
• OMIM: https://mirror.omim.org/entry/136538
• UniProt: http://www.uniprot.org/uniprot/P25090.html