N-formyl peptide receptor 3; FMLP-related receptor II; FMLP-R-II; formyl peptide receptor-like 2 (FPR3, FPRH1, FPRL2)

Function

• low affinity receptor for N-formyl-methionyl peptides, (neutrophils chemotactic factors)
• binding of FMLP to the receptor causes activation of neutrophils
• response is mediated via a G-protein that activates a phosphatidylinositol-Ca+2 second messenger system

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Additional terms

• fMet-Leu-Phe receptor; fMLP receptor; N-formyl peptide receptor; FPR; N-formylpeptide chemoattractant receptor (FPR1)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2359
• OMIM: https://mirror.omim.org/entry/136539
• UniProt: http://www.uniprot.org/uniprot/P25089.html