Ras GTPase-activating-like protein IQGAP2 (IQGAP2)

Function

• binds to activated CDC42 & RAC1
• does not seem to stimulate their GTPase activity of CDC42 or RAC1
• associates with calmodulin

Structure

• contains 1 CH (calponin-homology) domain
• contains 3 IQ domains
• contains 1 Ras-GAP domain
• contains 1 WW domain

Alternative splicing

named isoforms=2

Expression

isoform 2 expression is enhanced in testis

More general terms

• Ras GTPase-activating-like protein IQGAP

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10788
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10788
• OMIM: https://mirror.omim.org/entry/605401
• UniProt: http://www.uniprot.org/uniprot/Q13576.html