neurogenin-1; NGN-1; class A basic helix-loop-helix protein 6; bHLHa6; neurogenic basic-helix-loop-helix protein; neurogenic differentiation factor 3; neuroD3 (NEUROG1, BHLHA6, NEUROD3, NGN, NGN1)

Function

• acts as a transcriptional regulator
• role in the initiation of neuronal differentiation
• activates transcription by binding to the E box (5'-CANNTG-3')
• associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (putative)
• efficient DNA binding requires dimerization with another bHLH protein

Structure

• contains 1 basic helix-loop-helix (bHLH) domain

Compartment

nucleus (probable)

Expression

• expression restricted to the embryonic nervous system

More general terms

• neurogenic differentiation factor
• neurogenin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4762
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4762
• OMIM: https://mirror.omim.org/entry/601726
• UniProt: http://www.uniprot.org/uniprot/Q92886.html