alpha-1-acid glycoprotein 2; AGP 2; orosomucoid-2; OMD 2 (ORM2, AGP2)

Function

• transport protein in plasma
• binds various hydrophobic ligands in the interior of its beta-barrel domain
• also binds synthetic drugs & influences their distribution & availability
• appears modulate activity of the immune system during the acute-phase reaction

Structure

• N-glycosylated
• N-glycan heterogeneity at Asn-33:
  • hex5hexNAc4 (minor)
  • hex6hexNAc5 (major)
  • dhex1hex6hexNAc5 (minor)
• contains a beta-barrel that binds various ligands in its interior
• belongs to the calycin superfamily, lipocalin family

Compartment

secreted

Expression

• expressed by the liver & secreted into plasma
• expression is controlled by glucocorticoids, IL-1 & IL-6
• increases 5-50 fold upon inflammation

Polymorphism

• many different variants of ORM2 are known

More general terms

• alpha-1 acid glycoprotein; orosomucoid

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5005
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5005
• OMIM: https://mirror.omim.org/entry/138610
• UniProt: http://www.uniprot.org/uniprot/P19652.html