EF-hand domain-containing protein D2; Swiprosin-1 (EFHD2, SWS1)

Function

• may regulate B-cell receptor (BCR)-induced immature & primary B-cell apoptosis (putative)
• plays a role as negative regulator of the canonical NF-kappa-B-activating branch
• controls spontaneous apoptosis through the regulation of BCL2L1 abundance (putative)
• interacts with CASP9; with inactive form

Structure

contains 2 EF-hand domains

Compartment

• membrane raft (putative)

Expression

• found in lymphocytes
• preferentially expressed in CD8+ cells
• expressed in immature B-cell line WEHI231 (putative)

More general terms

• swiprosin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79180
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79180
• UniProt: http://www.uniprot.org/uniprot/Q96C19.html