2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD)

Function

• biosynthesis of NAD from tryptophan (kynurenine pathway)
  • compare with picolinate carboxylase
• converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS)

2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
           (--> 2-aminomuconate semialdehyde + CO2

Structure

• belongs to the ACMSD family

Alternative splicing

named isoforms=2

Pathology

• ACMS can be converted non-enzymatically to quinolate, a potent endogenous excitotoxin of neuronal cells implicated in pathogenesis of neurodegenerative disorders
• AMCSD convers ACMS to AMS, a benign catabolite

More general terms

• carboxy-lyase or decarboxylase

Additional terms

• picolinate carboxylase

Database

• OMIM: https://mirror.omim.org/entry/608889
• UniProt: http://www.uniprot.org/uniprot/Q8TDX5.html