sialyltransferase 10; type 2 lactosamine alpha-2,3-sialyltransferase; ST3gal VI (ST3GAL6, SIAT10)

Function

• role in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant
• as a alpha-2,3-sialyltransferase activity toward gal-beta1,4-GlcNAc structure on glycoproteins & glycolipids
• has a restricted substrate specificity, it utilizes gal-beta1,4-GlcNAc on glycoproteins, & neolactotetraosylceramide & neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1

Structure

belongs to the glycosyltransferase 29 family

Compartment

Golgi membrane

Expression

ubiquitous

More general terms

• sialyltransferase

Database

• OMIM: https://mirror.omim.org/entry/607156
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1040
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10402
• UniProt: http://www.uniprot.org/uniprot/Q9Y274.html