sialyltransferase 4C; beta-galactoside alpha-2,3-sialyltransferase; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase; alpha-3-N-acetylneuraminyltransferase; alpha-2,3-sialyltransferase; ST3GALIII; alpha 2,3-ST; GAL-NAC6S; STZ (SIAT4C, ST3GAL1, ST3GAL4, SAT-3, ST-4, CGS23)

Function

• may catalyze formation of the neuAc-alpha-2,3-gal-beta-1,3-galNAc- or neuAc-alpha-2,3-gal-beta-1,3-GlcNAc-sequences found in terminal carbohydrate groups of glycoproteins & glycolipids
• may be involved in biosynthesis of the sialyl Lewis X determinant
• protein modification; protein glycosylation
• the soluble form derives from the membrane form by proteolytic processing

CMP-N-acetylneuraminate + beta-D-galactosyl- 1,4-N-acetyl-D-glucosaminyl-glycoprotein
       <-->
CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N- acetyl-D-glucosaminyl-glycoprotein

Structure

belongs to the glycosyltransferase 29 family

Compartment

• Golgi, Golgi stack membrane
• secreted
• membrane-bound form in trans cisternae of Golgi
• secreted into the body fluid

Alternative splicing

named isoforms=5

Expression

• highly expressed in adult placenta, ovary & testes

More general terms

• sialyltransferase
• galactosyltransferase
• membrane protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q11206.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6484
• OMIM: https://mirror.omim.org/entry/104240
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6484