methyltransferase TARBP1 (TAR RNA-binding protein 1, TAR RNA-binding protein of 185 kD, TRP-185, TARBP1, TRM3, TRP185)

Function

• S-adenosyl-L-methionine-dependent methyltransferase (putative)
• methylates RNA molecules such as tRNAs

Structure

• monomer and homodimer.
• belongs to the RNA methyltransferase trmH family

Pathology

• in case of infection by HIV-1, it binds to loop region of TAR RNA, a region also bound by RNA polymerase 2
• binding of TARBP1 & RNA polymerase 2 to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase 2 from HIV-1 TAR RNA

may act by methylating HIV-1 TAR RNA

More general terms

• methyltransferase

Database

• OMIM: https://mirror.omim.org/entry/605052
• UniProt: http://www.uniprot.org/uniprot/Q13395.html