histone-lysine N-methyltransferase SETMAR (SET domain & mariner transposase fusion gene-containing protein, Metnase, Hsmar1, [Includes: Histone-lysine N-methyltransferase; Mariner transposase Hsmar1], SETMAR)
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Function
- histone methyltransferase
- methylates Lys-4 & Lys-36 of histone H3, 2 specific tags for epigenetic transcriptional activation
- mediates dimethylation of H3 Lys-36
- binds DNA via mariner transposase Hsmar1 region
- role in non-homologous end-joining repair (putative)
- no transposase activity because the active site contains an Asn in position 610 instead of a Asp residue
S-adenosyl-L-methionine + histone L-lysine <--> S-adenosyl-L-homocysteine + histone 6-N-methyl-L-lysine
Structure
- contains 1 post-SET domain
- contains 1 pre-SET domain
- contains 1 SET domain
- mariner transposase region present in primates appeared 40-58 million years ago, after insertion of a transposon downstream of a preexisting SET gene, followed by de novo exonization of previously non-coding sequence & creation of a new intron.
- N-terminal section; belongs to the histone-lysine methyltransferase family
- C-terminal section; belongs to the mariner transposase family
Compartment
Alternative splicing
named isoforms=2
Expression
- widely expressed
- highest expression in placenta & ovary
- lowest expression in skeletal muscle