protein phosphatase methylesterase 1; PME-1 (PPME1, PME1, PP2593 PRO0750)

Function

• demethylates proteins that have been reversibly carboxymethylated
• demethylates PPP2CB (in vitro) & PPP2CA
• binds protein phosphatase 2A (PPP2CA & PPP2CB)
• binding to PPP2CA displaces the Mn+2 & inactivates PPME1
• phosphorylated by SIK1 following increases in intracellular Na+, leading to dissociation from protein phosphatase 2A & subsequent dephosphorylation of Na+/K+-transporting ATPase ATP1A1 (putative)

Structure

belongs to the AB hydrolase superfamily

Alternative splicing

named isoforms=3

More general terms

• demethylase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51400
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51400
• OMIM: https://mirror.omim.org/entry/611117
• UniProt: http://www.uniprot.org/uniprot/Q9Y570.html