GMP reductase 2; guanosine 5'-monophosphate oxidoreductase 2; guanosine monophosphate reductase 2 (GMPR2)

Function

• <A15850>catalyzes</A15850> irreversible <A17822>NADPH</A17822>-dependent deamination of GMP to IMP
• functions in the conversion of nucleobase, nucleoside & nucleotide derivatives of G to A nucleotides, & in maintaining the intracellular balance of A & G nucleotides
• plays a role in modulating cellular differentiation

inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH

Structure

belongs to the IMPDH/GMPR family

Expression

• highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis & ovary
• low expression in colon, thymus & peripheral blood leukocytes

More general terms

• amine oxidoreductase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51292
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51292
• OMIM: https://mirror.omim.org/entry/610781
• UniProt: http://www.uniprot.org/uniprot/Q9P2T1.html