contactin-5; neural recognition molecule NB-2; hNB-2 (CNTN5)

Function

• contactins mediate cell surface interactions during nervous system development
• some neurite outgrowth-promoting activity in cerebral cortical neurons but not in hippocampal neurons
• neuronal activity in the auditory system (putative)
• interacts with PTPRG

Structure

• belongs to the immunoglobulin superfamily, contactin family
• contains 4 fibronectin F3 modules
• contains 6 Ig-like C2-type domains

Compartment

cell membrane, lipid-anchor, GPI-anchor

Alternative splicing

named isoforms=3

Expression

• expressed in brain, kidney > placenta
• not expressed in other tissues
• in brain, expressed in the occipital lobe, amygdala, cerebral cortex, frontal lobe, thalamus, temporal lobe > cerebellum, substantia nigra, putamen, medulla, hippocampus > spinal cord, caudate nucleus > corpus callosum

More general terms

• contactin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=53942
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:53942
• OMIM: https://mirror.omim.org/entry/607219
• UniProt: http://www.uniprot.org/uniprot/O94779.html