ankyrin repeat & SOCS box protein 14; ASB-14 (ASB14)
Jump to navigation
Jump to search
Function
- may be a substrate-recognition component of an elongin-Cullin-SOCS-box protein (ECS) E3 ligase complex which mediates ubiquitination & subsequent proteasomal degradation of target proteins
- protein modification; protein ubiquitination
Structure
- the SOCS box domain mediates the interaction with the elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (putative)
- contains 11 ANK repeats
- contains 1 SOCS box domain
Alternative splicing
named isoforms=2
Notes
- originally derived from a readthrough transcript including ASB14 & DNAH12