ankyrin repeat & SOCS box protein 8; ASB-8 (ASB8)
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Function
- may be a substrate-recognition component of an elongin-Cullin-SOCS-box protein (ECS) E3 ligase complex which mediates ubiquitination & subsequent proteasomal degradation of target proteins (putative)
- protein modification; protein ubiquitination
Structure
- the SOCS box domain mediates the interaction with the elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (putative)
- contains 4 ANK repeats
- contains 1 SOCS box domain
Compartment
Expression
- highest expression in skeletal muscle
- also expressed in heart, brain, placenta, liver, kidney & pancreas