kinesin-like protein KIF15; kinesin-like protein 2; hKLP2, kinesin-like protein 7; serologically defined breast cancer antigen NY-BR-62 (KIF15, KLP2, KNSL7)
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Function
- plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly (putative)
- interacts with MKI67 & TPX2
Structure
- belongs to the kinesin-like protein family, KLP2 subfamily
- contains 1 kinesin-motor domain
Compartment
- cytoplasm, spindle
- detected during interphase in the cytoplasm as finely punctuate pattern & irregularly shaped dots
- detected during mitosis on the mitotic spindle
- colocalizes with TPX2 in mitosis
- localizes at the central spindle at anaphase (putative)
- localizes at the sites of invaginating cell membranes, a position that corresponds to the location of the contractile actomyosin ring of dividing cells (putative)
- colocalizes with actin in interphase
- colocalizes in dendrites & in growth cone of axons with microtubules (putative)
Alternative splicing
named isoforms=4
Expression
expressed in testis, colon, tymus & in breast cancer