short transient receptor potential channel 6 (TrpC6, TRP6)

Function

• forms receptor-activated non-selective Ca+2 channel
• linked to phosphatidylinositol second messenger system activated by receptor tyrosine kinases or serpentine receptors (putative)
• activated by diacylglycerol, independently of PKC
• not activated by intracellular Ca+2 store depletion
• component of the glomerular slit diaphragm

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• expressed in placenta, lung, spleen, ovary small intestine
• expressed in podocytes

Pathology

• defects in TRPC6 result in focal segmental glomerulosclerosis 2

More general terms

• transmembrane 6 protein

Database

• OMIM: https://mirror.omim.org/entry/603652
• OMIM: https://mirror.omim.org/entry/603965
• UniProt: http://www.uniprot.org/uniprot/Q9Y210.html