membrane-spanning 4-domains subfamily A member 3 (hematopoietic-specific transmembrane 4 protein, HTm4, CD20 antigen-like protein, MS4A3, CD20L, HTM4)

Function

• hematopoietic modulator for the G1-S cell cycle transition
• modulates phosphorylation of cyclin-dependent kinase 2 (CDK2) via direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP)
• interacts with CDKN3
• interacts with CDKN3-CDK2 complexes through binding to CDKN3 via C-terminal region

Structure

• belongs to the MS4A family

Compartment

• intracytoplasmic membrane, cytoplasm, perinuclear region

Alternative splicing

named isoforms=2

Expression

• expressed specifically in hematopoietic cells & tissues

More general terms

• transmembrane 4 protein

Additional terms

• CD20; B-lymphocyte antigen CD20; membrane-spanning 4-domains subfamily A member 1; B-lymphocyte surface antigen B1; Leu-16; Bp35 (MS4A1)

Database

• OMIM: https://mirror.omim.org/entry/606498
• UniProt: http://www.uniprot.org/uniprot/Q96HJ5.html