bifunctional apoptosis regulator; RING finger protein 47 (BFAR, BAR, RNF47)

Function

• apoptosis regulator
• anti-apoptotic activity
  • apoptosis triggered via death-receptors
  • apoptosis triggered via mitochondrial factors
• interacts with CASP8, BCL2 & BCL2L1 through SAM domain, HIP1, ESRRBL1 BCAP31

Structure

• contains 1 RING-type Zn+2 finger
• contains 1 SAM (sterile alpha motif) domain

Compartment

• integral membrane protein
• endoplasmic reticulum

Expression

• expressed in brain > small intestine > testes > liver, skeletal muscle
• not expressed in heart, kidney, lung, spleen

More general terms

• transmembrane 4 protein
• ring finger protein
• phosphoprotein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51283
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51283
• UniProt: http://www.uniprot.org/uniprot/Q9NZS9.html