p53 apoptosis effector related to PMP-22; keratinocyte-associated protein 1; KCP-1; P53-induced protein PIGPC1; transmembrane protein THW (PERP, KCP1, KRTCAP1, PIGPC1, THW)

Function

• component of intercellular desmosome junctions
  • promotes desmosome assembly
• stratified epithelial integrity & cell-cell adhesion
• effector in p53-dependent apoptotic pathway

Structure

belongs to the TMEM47 family

Compartment

associated with desmosomes

Alternative splicing

named isoforms=2

Expression

• expressed in skin, heart, placental, liver, pancreas, keratinocytes, dermal fibroblasts

More general terms

• transmembrane 4 protein

Additional terms

• apoptosis
• cellular tumor antigen p53; tumor suppressor p53, phosphoprotein p53; antigen NY-CO-13 (TP53, p53)
• keratinocytes-associated protein (KRTCAP)
• peripheral myelin protein 22; PMP-22; growth arrest-specific protein 3; GAS-3 (PMP22, GAS3)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64065
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64065
• OMIM: https://mirror.omim.org/entry/609301
• UniProt: http://www.uniprot.org/uniprot/Q96FX8.html