mucin-20 (MUC-20, MUC20, KIAA1359, UNQ2782/PRO7170)

Function

• may regulate MET signaling cascade
• seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation
• blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway
• inhibits HGF-induced proliferation of MMP1 & MMP9 expression
• oligomerization is required for interaction with MET

Compartment

• secreted (putative), cell membrane
• localized in the proximal tubules, specifically in the brush border & basolateral membrane
• isoform 3, isoform 5 & isoform 9 are membrane proteins

Alternative splicing

named isoforms=9

Expression

• highly expressed in kidney, moderately in placenta, lung, prostate, liver, & digestive system
• in the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules
• detected in most of the male urogenital tract epithelia, with the exception of epididymis

Pathology

• up-regulated in patients with immunoglobulin A nephropathy (IgAN)
• no significant difference in frequencies of alleles or genotypes of tandem repeats between IgAN patients & healthy controls

More general terms

• mucin

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2009
• UniProt: http://www.uniprot.org/uniprot/Q8N307.html