interleukin-21 receptor; IL-21R; novel interleukin receptor (IL21R, NILR, UNQ3121/PRO10273)

Function

• receptor for interleukin-21
• heterodimer with the common gamma chain.
• associates with JAK1

Structure

• the WSXWS motif appears to be necessary for proper protein folding, efficient intracellular transport & cell- surface receptor binding
• the box 1 motif is required for JAK interaction &/or activation
• belongs to the type I cytokine receptor family, type 4 subfamily
• contains 1 fibronectin F3 module

Compartment

membrane

Expression

• selectively expressed in lymphoid tissues
• most highly expressed in thymus & spleen

More general terms

• interleukin receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5061
• OMIM: https://mirror.omim.org/entry/605383
• UniProt: http://www.uniprot.org/uniprot/Q9HBE5.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=50615