interleukin-17 receptor B; IL-17 receptor B; IL-17RB; interleukin-17B receptor; IL-17B receptor; IL-17 receptor homolog 1; IL-17Rh1; IL17Rh1; cytokine receptor CRL4 (IL17RB, EVI27, IL17BR, UNQ2501/PRO19612)

Function

• receptor for the proinflammatory cytokines IL17B & IL17E
• may play a role in controlling the growth &/or differentiation of hematopoietic cells
• interacts with DAZAP2

Structure

contains 1 SEFIR domain

Compartment

• isoform 1: cell membrane
• isoform 2: secreted

Alternative splicing

named isoforms=2

Expression

• expressed in several endocrine tissues
• expresses in fetal & adult liver, kidney, pancreas, testis, colon, brain & small intestine
• not detected in peripheral blood leukocytes, lymphoid organs, & most cell lines

Laboratory

• HOXB13/IL17BR gene ratio

Notes

• may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

More general terms

• interleukin-17 receptor (IL17R)
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5554
• OMIM: https://mirror.omim.org/entry/605458
• UniProt: http://www.uniprot.org/uniprot/Q9NRM6.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55540