LIM/homeobox protein LHX1; LIM homeobox protein 1; homeobox protein Lim-1; hLim-1 (LHX1, LIM1)

Function

• transcription factor (putative)
• may play a role in early mesoderm formation & later in lateral mesoderm differentiation & neurogenesis
• interacts with LDB1 via the tandem LIM domains

Structure

• the LIM domains exert a negative regulatory function; disruption of the LIM domains produces an activated form
• 2 activation domains & a negative regulatory domain exist C-terminal to the homeobox (putative)
• contains 1 homeobox DNA-binding domain
• contains 2 LIM Zn+2-binding domains

Compartment

nucleus (probable)

Expression

• expressed in brain, thymus, & tonsils

Pathology

• expressed in leukocytes in chronic myeloid leukemia
• expressed in 58% of acute myeloid leukemia (AML) cell lines

More general terms

• LIM/homeodomain protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3975
• OMIM: https://mirror.omim.org/entry/601999
• UniProt: http://www.uniprot.org/uniprot/P48742.html