zinc finger protein 649 (ZNF649)

Function

• transcriptional repressor; KRAB domain is required for transcriptional repression
• regulator of transcriptional factor complexes
• suppresses SRE & AP1 transcription activities mediated by growth factor signaling pathways

Structure

• belongs to the krueppel C2H2-type zinc-finger protein family
• contains 10 C2H2-type zinc fingers
• contains 1 KRAB domain

Compartment

nucleus

Expression

• expressed in heart, skeletal muscle, brain > liver, lung, kidney, pancreas, placenta
• expressed in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas

More general terms

• C2H2 type zinc finger protein
• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BS31.html