zinc finger protein 175; zinc finger protein OTK18 (ZNF175)

Function

• down-regulates the expression of several chemokine receptors
• interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 15 C2H2-type Zn+2 fingers
• contains 1 KRAB domain

Compartment

cytoplasm, nucleus

Expression

• ubiquitous
• induced by HIV type 1 infection

More general terms

• C2H2 type zinc finger protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7728
• OMIM: https://mirror.omim.org/entry/601139
• UniProt: http://www.uniprot.org/uniprot/Q9Y473.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7728