zinc finger protein OZF; only zinc finger protein; zinc finger protein 146 (ZNF146, OZF)

Function

• binds DNA.
• interacts with SUMO conjugating enzyme UBC9/UBE2I
• interacts with the telomeric protein TERF2IP
• sumoylated

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 10 C2H2-type Zn+2 fingers

Compartment

nucleus

Expression

• liver, skeletal & heart muscle, mammary cells
• very low levels in brain, lung, placenta & kidney

Pathology

• strongly overexpressed in many pancreas & colorectal cancers
• increased gene copy numbers are detected in 3 of 12 tumor cell lines & 2 of 12 primary pancreatic carcinomas
• overexpresseed in 80% of colorectal cancers

More general terms

• DNA-binding protein
• C2H2 type zinc finger protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7705
• OMIM: https://mirror.omim.org/entry/601505
• UniProt: http://www.uniprot.org/uniprot/Q15072.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7705