zinc finger protein 41 (ZNF41)

Function

• may be involved in transcriptional regulation

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 18 C2H2-type Zn+2 fingers
• contains 1 KRAB domain

Compartment

nucleus (putative)

Alternative splicing

• named isoforms=8
• additional isoforms seem to exist

Expression

• expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney & pancreas

Pathology

• defects in ZNF41 are the cause of non-syndromic mental retardation X-linked type 89
• chromosomal translocation t(X;7)(p11.3;q11.21) involving ZNF41 has been found in a patient with severe mental retardation.

More general terms

• transcription factor (TF)
• C2H2 type zinc finger protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7592
• OMIM: https://mirror.omim.org/entry/314995
• UniProt: http://www.uniprot.org/uniprot/P51814.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7592