mutS protein homolog 5; hMSH5 (MSH5)

Function

• role in meiotic recombination
• facilitates crossovers between homologs during meiosis (putative)
• heterooligomer of MSH4 & MSH5
• interacts with HJURP

Structure

belongs to the DNA mismatch repair mutS family

Alternative splicing

named isoforms=4

Expression

• ubiquitous, but highly expressed in testis, & thymus

More general terms

• mutS family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4439
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4439
• OMIM: https://mirror.omim.org/entry/603382
• UniProt: http://www.uniprot.org/uniprot/O43196.html