lysine-specific demethylase 2A; JmjC domain-containing histone demethylation protein 1A; [histone-H3]-lysine-36 demethylase 1A; F-box/LRR-repeat protein 11; F-box & leucine-rich repeat protein 11; F-box protein FBL7; F-box protein Lilina; CXXC-type zinc finger protein 8 (KDM2A, CXXC8, FBL7, FBXL11, JHDM1A, KIAA1004)

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Function

histone demethylase
demethylates Lys-36 of histone H3
- preferentially demethylates dimethylated H3 Lys-36 with weak or no activity for mono- & tri-methylated H3 Lys-36
role in histone code
recognizes & binds to phosphorylated proteins & promotes their ubiquitination & degradation (putative)
required to maintain the heterochromatic state
associates with centromeres & represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere
required to sustain centromeric integrity & genomic stability, particularly during mitosis
component of SKP1-cullin-F-box protein ligase complex (SCF complex)
interacts with CBX5/HP1A; the interaction promotes CBX5 localization to chromatin

protein N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O2
                  <-->
protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO2

protein N(6)-methyl-L-lysine + 2-oxoglutarate + O2
                 <-->
protein L-lysine + succinate + formaldehyde + CO2

Cofactor: binds 1 Fe+2 ion per subunit

the JmjC domain mediates demethylation activity & is required for satellite silencing
belongs to the JHDM1 histone demethylase family
contains 1 CXXC-type Zn+2 finger
contains 1 F-box domain
contains 1 JmjC domain
contains 3 LRR repeats (leucine-rich repeats)
contains 1 PHD-type Zn+2 finger

nucleus, nucleoplasm
punctate expression throughout the nucleoplasm & enriched in the perinucleolar region

widely expressed: brain, testis, ovary > lung