F-box/LRR-repeat protein 4; F-box & leucine-rich repeat protein 4; F-box protein FBL4/FBL5 (FBXL4 FBL4 FBL5)

Function

• recognizes & binds to phosphorylated proteins & promotes their ubiquitination & degradation (putative)
• interacts with SKP1
• component of SKP1-cullin-F-box protein ligase complex (SCF complex)

Structure

• contains 1 F-box domain
• contains 8 LRR repeats (leucine-rich repeats)

Compartment

cytoplasm, nucleus

Expression

• expressed in heart, kidney, liver, lung, pancreas, placenta
• not expressed in skeletal muscle

More general terms

• F-box & leucine-rich repeat protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26235
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26235
• OMIM: https://mirror.omim.org/entry/605654
• UniProt: http://www.uniprot.org/uniprot/Q9UKA2.html