F-box & leucine-rich repeat protein-2 (FBXL2, F-box/LRR-repeat protein 2, F-box protein FBL2/FBL3)

Function

• recognizes & binds to phosphorylated proteins & promotes their ubiquitination & degradation (putative)
• interacts with SKP1
• component of SKP1-cullin-F-box protein ligase complex (SCF complex)

Structure

• contains 1 F-box domain
• contains 11 LRR repeats (leucine-rich repeats)

Expression

• expressed in brain, heart, kidney, liver, lung, pancreas, placenta

More general terms

• F-box & leucine-rich repeat protein

Component of

• SCF-type E3 ligase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=25827
• OMIM: https://mirror.omim.org/entry/605652
• UniProt: http://www.uniprot.org/uniprot/Q9UKC9.html