acyl-coenzyme A thioesterase 8; acyl-CoA thioesterase 8; choloyl-coenzyme A thioesterase; HIV-Nef-associated acyl-CoA thioesterase; PTE-2; peroxisomal acyl-coenzyme A thioester hydrolase 1; PTE-1; peroxisomal long-chain acyl-CoA thioesterase 1; thioesterase II; hACTE-III; hACTEIII; hTE (ACOT8, ACTEIII, PTE1, PTE2)

Function

• acyl-CoA thioesterases are a group of enzymes that catalyze hydrolysis of acyl-CoAs to the free fatty acid & coenzyme A
• may regulate intracellular levels of acyl-CoAs, free fatty acids & coenzyme A
• may mediate Nef-induced down-regulation of CD4
• major thioesterase in peroxisomes
• competes with BAAT (bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA)
• preference f.or medium-length fatty acyl-CoAs (putative)
• may be involved in metabolic regulation of peroxisome proliferation
• interacts with HIV-1 Nef

choloyl-CoA + H2O = cholate + CoA

Structure

belongs to the C/M/P thioester hydrolase family

Compartment

peroxisome

Expression

• ubiquitous
• detected in a T-cell line (at protein level)
• regulated by peroxisome proliferator (such as Clofibrate), via the peroxisome proliferator-activated receptors (PPARs) (putative)

More general terms

• thiol esterase or thioesterase
• phosphoprotein

Additional terms

• peroxisome

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10005
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10005
• OMIM: https://mirror.omim.org/entry/608123
• UniProt: http://www.uniprot.org/uniprot/O14734.html