casein kinase 1 epsilon (CSNK1E)

Function

• casein kinase
• participates in Wnt signaling
• phosphorylates DVL1
• central component of the circadian core oscillator (circadian clock)
• may act as a negative regulator of circadian rhythmicity by phosphorylating PER1 & PER2 & lead to their degradation
• retains PER1 in the cytoplasm
• interacts with ANKRD6 & SOCS3
• inhibits cytokine-induced granuloytic differentiation
• autophosphorylated (putative)

Structure

• monomer
• belongs to the protein kinase superfamily, CK1 Ser/Thr protein kinase family, casein kinase I subfamily
• contains 1 protein kinase domain

Compartment

cytoplasm (putative)

Expression

• expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta & skeletal muscle
• expressed in monocytes & lymphocytes but not in granulocytes
• down-regulated during granulocytic differentiation

More general terms

• casein kinase 1

Database

• UniProt: http://www.uniprot.org/uniprot/P49674.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1454
• OMIM: https://mirror.omim.org/entry/600863
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1454