ankyrin repeat domain-containing protein 6; diversin (ANKRD6, KIAA0957)

Function

• recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 & GSK3-beta & allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals (putative)
• interacts with AXN1, AXN2 & CSNK1E/CKI-epsilon

Structure

contains 8 ANK repeats

Alternative splicing

named isoforms=3

More general terms

• ankyrin repeat domain protein (ANKRD)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22881
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:22881
• OMIM: https://mirror.omim.org/entry/610583
• UniProt: http://www.uniprot.org/uniprot/Q9Y2G4.html