ubiquitin carboxyl-terminal hydrolase 46; deubiquitinating enzyme 46; ubiquitin thiolesterase 46; ubiquitin-specific-processing protease 46 (USP46)

Function

• deubiquitinating enzyme
• plays a role in behavior, possibly by regulating GABA action
• may act by mediating deubiquitination of GAD1/GAD67
• has almost no deubiquitinating activity by itself & requires the interaction with WDR48 to have a high activity
• not involved in deubiquitination of monoubiquitinated FANCD2
• thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin
• interacts with WDR48

Structure

• belongs to the peptidase C19 family, USP12/USP46 subfamily

Alternative splicing

named isoforms=4

Expression

broadly expressed

More general terms

• ubiquitin C-terminal hydrolase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64854
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64854
• OMIM: https://mirror.omim.org/entry/612849
• UniProt: http://www.uniprot.org/uniprot/P62068.html