glutamate decarboxylase 1 (glutamate decarboxylase 67 kD isoform, GAD1, GAD67)

Function

• catalyzes production of GABA

L-glutamate <--> 4-aminobutanoate + CO2

Cofactor: pyridoxal phosphate

Structure

• homodimer
• belongs to the group II decarboxylase family

Alternative splicing

named isoforms=3

Expression

• expressed in brain
• isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, & perhaps other endocrine tissues but not expressed in brain

Pathology

• defects in GAD1 are the cause of autosomal recessive symmetric spastic cerebral palsy

More general terms

• glutamate decarboxylase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2571
• OMIM: https://mirror.omim.org/entry/603513
• OMIM: https://mirror.omim.org/entry/605363
• UniProt: http://www.uniprot.org/uniprot/Q99259.html