ubiquitin carboxyl-terminal hydrolase 12; deubiquitinating enzyme 12; ubiquitin thiolesterase 12; ubiquitin-hydrolyzing enzyme 1; ubiquitin-specific-processing protease 12 (USP12, UBH1, USP12L1)

Function

• deubiquitinating enzyme
• has almost no deubiquitinating activity by itself; requires interaction with WDR48 to have high activity
• not involved in deubiquitination of monoubiquitinated FANCD2
• thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin
• interacts with WDR48

Structure

• belongs to the peptidase C19 family, USP12/USP46 subfamily

More general terms

• ubiquitin C-terminal hydrolase

Additional terms

• ubiquitin (UBCEP2, UBB, UBC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=219333
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:219333
• OMIM: https://mirror.omim.org/entry/603091
• UniProt: http://www.uniprot.org/uniprot/O75317.html