ubiquitin carboxyl-terminal hydrolase 11; deubiquitinating enzyme 11; ubiquitin thiolesterase 11; ubiquitin-specific-processing protease 11 (USP11, UHX1)

Function

• protease that can remove conjugated ubiquitin from target proteins & polyubiquitin chains
• inhibits degradation of target proteins by the proteasome
• plays a role in the regulation of pathways leading to NF-kappa-B activation
• plays a role in the regulation of DNA repair after double-stranded DNA breaks
• thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin
• interacts with RANBP9/RANBPM. interacts with BRCA2, CHUK/IKKA & NFKBIA
• interacts with papilloma virus protein 16E7

Structure

• belongs to the peptidase C19 family
• contains 1 DUSP domain

Compartment

• nucleus, cytoplasm
• predominantly nuclear
• associates with chromatin

Notes

• it is uncertain whether Met-1 or Met-44 is the initiator

More general terms

• ubiquitin C-terminal hydrolase
• nuclear protein
• phosphoprotein

Additional terms

• ubiquitin (UBCEP2, UBB, UBC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8237
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8237
• OMIM: https://mirror.omim.org/entry/300050
• UniProt: http://www.uniprot.org/uniprot/P51784.html