P2Y11 purinoceptor; P2Y purinoceptor 11; P2Y11 (P2RY11)

Function

• receptor for ATP & ADP
• coupled to G-proteins that activate both phosphatidylinositol-Ca+2 & adenylyl cyclase second messenger systems
• not activated by UTP or UDP

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane; multi-pass membrane protein

Expression

• highest expression in spleen, lower in small intestine
• expression increased by DMSO & retinoic acid

Genetics

• a putative trans-splicing which involves PPAN & P2RY11 gene regions produces a fusion protein

More general terms

• P2Y purinoceptor or P2Y purinergic receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5032
• OMIM: https://mirror.omim.org/entry/602697
• UniProt: http://www.uniprot.org/uniprot/Q96G91.html